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ST247

Cat. No. M8337

All AbMole products are for research use only, cannot be used for human consumption.

ST247 Structure

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Quality Control & Documentation
Biological Activity

ST247 is a PPAR β/δ selective inverse agonist. The compound is based on the structure of GSK0660, and is 10-fold more potent in blocking the transcription of endogenous target genes: ST247 IC50 = 19 nm vs. GSK0660 IC50 = 210 nM.

Chemical Information
Molecular Weight 426.55
Formula C19H26N2O5S2
CAS Number 1356497-91-0
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Franziska Kleinert, et al. Draft Genome Sequences of Three Northern German Epidemic Staphylococcus aureus (ST247) Strains Containing Multiple Copies of IS256

[2] E Lpez-Collazo, et al. Response to "In vivo attenuation and genetic evolution of a ST247-SCCmecI MRSA clone after 13 years of pathogenic bronchopulmonary colonization in a patient with cystic fibrosis: implications of the innate immune response"

[3] William L Kelley, et al. Missense mutations in PBP2A Affecting ceftaroline susceptibility detected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus clonotypes ST228 and ST247 in Western Switzerland archived since 1998

[4] E Lpez-Collazo, et al. In vivo attenuation and genetic evolution of a ST247-SCCmecI MRSA clone after 13 years of pathogenic bronchopulmonary colonization in a patient with cystic fibrosis: implications of the innate immune response

[5] Simone Naruhn, et al. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties

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