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Cat. No. M25558
Spexin Structure

Neuropeptide Q

Size Price Availability Quantity
1mg USD 195  USD195 In stock
5mg USD 470  USD470 In stock
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Quality Control & Documentation
Biological Activity

Spexin is a conserved peptide plays roles of neurotransmitter/neuromodulator and endocrine factor.

Chemical Information
Molecular Weight 1619.88
Formula C74H114N20O19S
CAS Number 1370290-58-6
Form Solid
Solubility (25°C) Water 20 mg/mL
Storage Store at ≤ -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Andy Tran, et al. Pharmacol Ther. Spexin: Its role, regulation, and therapeutic potential in the hypothalamus

[2] Penghua Fang, et al. Ageing Res Rev. Adipose tissue spexin in physical exercise and age-associated diseases

[3] Maryam Behrooz, et al. J Diabetes Metab Disord. Spexin status in relation to obesity and its related comorbidities: a systematic review

[4] Edouard G Mills, et al. Nat Rev Endocrinol. Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

[5] Liping Gu, et al. Int J Biol Sci. Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells

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Keywords: Spexin, Neuropeptide Q supplier, Neuropeptide Receptor, inhibitors, activators

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