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Soporidine

Cat. No. M27730
Soporidine Structure
Synonym:

RG4; SOP

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Biological Activity

Soporidine is an antagonist of germination of the parasitic plant Striga hermonthica. Soporidine specifically inhibits a S. hermonthica strigolactone receptor and inhibits the parasite's germination.

Chemical Information
Molecular Weight 473.53
Formula C27H30F3NO3
CAS Number 1060376-43-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jinping Liang, et al. J Leukoc Biol. Sophoridine inhibits endotoxin-induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation

[2] Qi Wang, et al. Phytomedicine. Sophoridine: A review of its pharmacology, pharmacokinetics and toxicity

[3] Zhiyang Peng, et al. BMC Cancer. Sophoridine exerts tumor-suppressive activities via promoting ESRRG-mediated β-catenin degradation in gastric cancer

[4] Haroon Ur Rashid, et al. Bioorg Chem. Anti-cancer potential of sophoridine and its derivatives: Recent progress and future perspectives

[5] Rui Wang, et al. Mol Cancer Res. Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2

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  Catalog
Abmole Inhibitor Catalog




Keywords: Soporidine, RG4; SOP supplier, Parasite, inhibitors, activators


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