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Sofalcone is a gastric antiulcer agent, it is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. Sofalcone (50 μmol/L) significantly increases HO-1 mRNA expression compare with the control group in both trophoblasts and HUVECs (P<0.05 for both). Sofalcone significantly decreases the sFlt-1 concentrations in the culture media and dose dependently decreases the amount of THP-1 monocyte adherence to HUVECs.
| Molecular Weight | 450.52 |
| Formula | C27H30O6 |
| CAS Number | 64506-49-6 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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