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Sivelestat sodium tetrahydrate

Cat. No. M5966
Sivelestat sodium tetrahydrate Structure
Synonym:

Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium

Size Price Availability Quantity
10mg USD 80  USD80 In stock
50mg USD 280  USD280 In stock
100mg USD 388  USD388 In stock
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Quality Control
Biological Activity

Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 528.51
Formula C20H21N2O7S.4H2O.Na
CAS Number 201677-61-4
Purity 100.0%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

[1] Miyoshi S, et al. Drug Des Devel Ther. Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sivelestat sodium tetrahydrate, Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium supplier, Proteasome, inhibitors

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