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Sivelestat sodium tetrahydrate

Cat. No. M5966
Sivelestat sodium tetrahydrate Structure
Synonym:

Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium

Size Price Availability Quantity
10mg USD 80  USD80 In stock
50mg USD 280  USD280 In stock
100mg USD 388  USD388 In stock
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Quality Control & Documentation
Biological Activity

Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.

Product Citations
Chemical Information
Molecular Weight 528.51
Formula C20H21N2O7S.4H2O.Na
CAS Number 201677-61-4
Solubility (25°C) 100 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Miyoshi S, et al. Drug Des Devel Ther. Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients.

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Keywords: Sivelestat sodium tetrahydrate, Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium supplier, Elastase, inhibitors, activators


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