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Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.
EBioMedicine. 2023 Aug 4;95:104739.
Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice
Sivelestat sodium tetrahydrate purchased from AbMole
| Molecular Weight | 528.51 |
| Formula | C20H21N2O7S.4H2O.Na |
| CAS Number | 201677-61-4 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Elastase Products |
|---|
| Ala-Ala-Pro-Val-chloromethylketone
Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases. |
| MeOSuc-Ala-Ala-Pro-Met-AMC
MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases. |
| Suc-Ala-Ala-Pro-Val-AMC
Suc-Ala-Ala-Pro-Val-AMC, a tetrapeptide, is an elastasesubstrate. |
| Suc-Ala-Ala-Ala-AMC
Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like. |
| Suc-Ala-Pro-Ala-AMC
Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase. |
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