About 32 results found for searched term "Elastase" (0.103 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10276 | Elastase (from porcine pancreas) | Animal Modeling |
| Pancreatopeptidase E | ||
| Elastase from porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. | ||
| M42348 | Neutrophil elastase inhibitor 4 | Elastase |
| Neutrophil elastase inhibitor 4 is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM, Ki: 8.04 nM). | ||
| M50352 | Elastase | Enzymes & Coenzymes |
| Elastase is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M3636 | Leupeptin hemisulfate | Cathepsin |
| Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin. | ||
| M4326 | Chrysophanol-8-O-β-D-glucopyranoside | Elastase |
| Chrysophanol 8-O-glucoside is derived from the root of Rumex acetosa and has moderate elastase inhibitory activity. | ||
| M5147 | GW311616 | Elastase |
| GW-311616 | ||
| GW311616 is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM and Ki value of 0.31 nM. | ||
| M5148 | GW311616 hydrochloride | Elastase |
| GW311616A | ||
| GW311616 HCl (GW311616A) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM. | ||
| M5402 | Alvelestat (AZD9668) | Elastase |
| AZD9668 | ||
| Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. | ||
| M5966 | Sivelestat sodium tetrahydrate | Elastase |
| Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium | ||
| Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse. | ||
| M6024 | Tranexamic Acid | Others |
| cyclocapron | ||
| Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis. | ||
| M7083 | ONO 6818 | Others |
| ONO 6818 is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active. | ||
| M7297 | Sivelestat sodium salt | Elastase |
| ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium | ||
| Sivelestat sodium salt is a selective leukocyte elastase inhibitor. | ||
| M7333 | SSR 69071 | Others |
| SSR 69071 is a potent, orally active human leukocyte elastase inhibitor. | ||
| M8577 | BAY-678 | Others |
| BAY-678 is an orally available, highly potent and selective inhibitor of human neutrophil elastase (HNE). | ||
| M9133 | AKBA | Lipoxygenase |
| 3-O-Acetyl-11-keto-β-boswellic acid; Acetyl-11-keto-β-boswellic acid | ||
| AKBA is an active triterpenoid compound from the extract of Boswellia serrata and Boswellia carteri Birdw, exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. | ||
| M9550 | Sivelestat | Elastase |
| ONO5046; LY544349; EI546 | ||
| Sivelestat (ONO5046; LY544349; EI546) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. | ||
| M14332 | BAY-85-8501 | Elastase |
| BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM. | ||
| M14333 | DMP 777 | Elastase |
| L-694458 | ||
| DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. | ||
| M14760 | (R)-BAY-85-8501 | Others |
| (R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM. | ||
| M28045 | GB83 | PAR |
| GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons. | ||
| M28084 | JCP174 | Elastase |
| JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase. | ||
| M29588 | BOS-318 | Others |
| BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease. | ||
| M29691 | CH 5450 | Peptides |
| Z-Ile-Glu-Pro-Phe-Ome | ||
| CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC50 value of 49 µM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC50 value of 4.8 µM. | ||
| M29801 | Tutuilamide A | Elastase |
| Tutuilamide A is a potent porcine pancreatic elastase (PPE) inhibitor, with an IC50 of 1.2 nM. Tutuilamide A also inhibits human neutrophil elastase (HNE; IC50=0.73 nM) and kallikrein 7 (KLK7; IC50=5.0 nM). | ||
| M39077 | Skullcapflavone I | Elastase |
| Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a. | ||
| M40258 | Isoarjunolic acid | Others |
| Isoarjunolic acid (2α,3α,23-Trihydroxyolean-12-en-28-oic acid) is a triterpenoid, can be isolated from the stems of Cornus kousa. Isoarjunolic acid could have free radical scavenging activity and elastase inhibition activity . | ||
| M40914 | Rivulariapeptolides 1155 | Serine/Threonine Protease |
| Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50 values of 41.84 nM, 4.94 nM, and 56.54 nM for chymotrypsin, elastase, and proteinase K, respectively. | ||
| M40915 | Rivulariapeptolides 988 | Serine/Threonine Protease |
| Rivulariapeptolides 988 is a potent and selective serine protease inhibitor with IC50 values of 95.46 nM, 15.29 nM and 85.50 nM for tryptic coagulase, elastase and proteinase K, respectively. | ||
| M40916 | Rivulariapeptolides 1185 | Serine/Threonine Protease |
| Rivulariapeptolides 1185 is a potent and selective serine protease inhibitor with IC50 values of 13.17 nM, 23.59 nM, and 55.26 nM for tryptic coagulase, elastase, and proteinase K, respectively. | ||
| M40917 | Rivulariapeptolides 1121 | Serine/Threonine Protease |
| Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM, and 48.05 nM for tryptic coagulase, elastase, and proteinase K, respectively. | ||
| M42336 | ONO-EI-601 | Metabolite/Endogenous Metabolite |
| ONO-EI-601 is the major metabolite of human neutrophil elastase inhibitor ONO-5046. | ||
| M42346 | KLK7/ELA2-IN-1 | Elastase |
| KLK7/ELA2-IN-1 is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC50s of 6 nM and 55 nM, respectively. | ||
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