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Elastase (from porcine pancreas)

Cat. No. M10276
Elastase (from porcine pancreas) Structure
Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Elastase from porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide.

Chemical Information
Molecular Weight 25898.13
CAS Number 39445-21-1
Solubility (25°C) Water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] T Teshima, et al. J Biol Chem. A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates

[2] D M Shotton, et al. Nature. Amino-acid sequence of porcine pancreatic elastase and its homologies with other serine proteinases

[3] P J Stone, et al. Am Rev Respir Dis. Induction and exacerbation of emphysema in hamsters with human neutrophil elastase inactivated reversibly by a peptide boronic acid

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Keywords: Elastase (from porcine pancreas) supplier, Animal Modeling, inhibitors, activators

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