Free shipping on all orders over $ 500

Elastase (from porcine pancreas)

Cat. No. M10276
Elastase (from porcine pancreas) Structure
Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 120  USD120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Elastase from porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide.

Chemical Information
Molecular Weight 25898.13
CAS Number 39445-21-1
Solubility (25°C) Water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] T Teshima, et al. J Biol Chem. A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates

[2] D M Shotton, et al. Nature. Amino-acid sequence of porcine pancreatic elastase and its homologies with other serine proteinases

[3] P J Stone, et al. Am Rev Respir Dis. Induction and exacerbation of emphysema in hamsters with human neutrophil elastase inactivated reversibly by a peptide boronic acid

Related Animal Modeling Products
N-Butyl-N-(4-hydroxybutyl)nitrosamine

N-Butyl-N-(4-hydroxybutyl)nitrosamine can be used to construct animal models of bladder cancer (BLCA).

Boromycin

Boromycin is a compound isolated from Streptomyces antibioticus and a boron-containing macrolide antibiotic with potent activity against a number of viruses, gram-positive bacteria and protozoan parasites. It can be used to induce a mouse model of pulmonary fibrosis and can be used in malaria-related studies.

Dextrose iron

Dextrose iron can be used to construct animal models of iron overload.

Prednisone acetate

Prednisone acetate is the acetate form of Prednisone and a glucocorticoid receptor agonist with anti-inflammatory and immunomodulatory properties. It can be used to construct animal models of Kawasaki disease.

Carrageenan

Carrageenan is a biochemical reagent that can be used to construct animal models of chronic non-bacterial prostatitis, models of synovitis, and models of prostatitis.

  Catalog
Abmole Inhibitor Catalog




Keywords: Elastase (from porcine pancreas) supplier, Animal Modeling, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.