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Sinensetin

Cat. No. M4658
Sinensetin Structure
Synonym:

Pedalitin permethyl ether

Size Price Availability Quantity
20mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties.

Chemical Information
Molecular Weight 372.37
Formula C20H20O7
CAS Number 2306-27-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dong Yang, et al. Sinensetin attenuates oxygen-glucose deprivation/reperfusion-induced neurotoxicity by MAPK pathway in human cerebral microvascular endothelial cells

[2] Lee Han Jie, et al. Sinensetin: An Insight on Its Pharmacological Activities, Mechanisms of Action and Toxicity

[3] Dan Liu, et al. Inhibitory mechanism of sinensetin on α-glucosidase and non-enzymatic glycation: Insights from spectroscopy and molecular docking analyses

[4] Jiashun Li, et al. Sinensetin suppresses influenza a virus-triggered inflammation through inhibition of NF-κB and MAPKs signalings

[5] Kok-Tong Tan, et al. Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma

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Keywords: Sinensetin, Pedalitin permethyl ether supplier, PGE synthase, inhibitors, activators


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