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PGE synthase Prostaglandin E synthase


Cat.No.  Name Information
M1737 MF63 MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme respectively.
M8896 MDK36122 MDK36122, also known as H-PGDS Inhibitor I, is a Prostaglandin D Synthase (hematopoietic-type) Inhibitor with an IC50 Value of 0.7 nM.
M6067 Zomepirac sodium salt Zomepirac Sodium is a pyrrole-acetic acid structurally related to tolmetin sodium; a prostaglandin synthetase inhibitor.
M4948 SAR191801 hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.
M4658 Sinensetin Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties.
M3788 HQL-79 HQL-79 is a selective inhibitor of human hematopoietic prostaglandin D (PGD) synthase (H-PGDS) (IC50 = 6 μM).
M2446 Benzydamine hydrochloride Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory compound (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
M42036 Friluglanstat Friluglanstat is a prostaglandin E synthase (mPGES-1) inhibitor, with anti-inflammatory activity.
M42035 UT-11 UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor.
M30939 CAY10526  CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1.
M29232 HPGDS inhibitor 2  HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM.
M28159 PF-4693627  PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).
M14105 Limaprost Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research.

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