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Zomepirac sodium salt

Cat. No. M6067
Zomepirac sodium salt Structure
Synonym:

McN-2783-21-98

Size Price Availability
100mg USD 60  USD60 Out of stock
500mg USD 100  USD100 Out of stock
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Quality Control & Documentation
Biological Activity

Zomepirac Sodium is a pyrrole-acetic acid structurally related to tolmetin sodium; a prostaglandin synthetase inhibitor.

Chemical Information
Molecular Weight 313.71
Formula C15H13ClNNaO3
CAS Number 64092-48-4
Solubility (25°C) 100 mg/mL in water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Iwamura A, et al. Drug Metab Dispos. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice.

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Keywords: Zomepirac sodium salt, McN-2783-21-98 supplier, PGE synthase, inhibitors, activators


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