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Zomepirac sodium salt

Cat. No. M6067
Zomepirac sodium salt Structure
Synonym:

McN-2783-21-98

Size Price Availability Quantity
100mg USD 70  USD70 In stock
500mg USD 100  USD100 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Zomepirac Sodium is a pyrrole-acetic acid structurally related to tolmetin sodium; a prostaglandin synthetase inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 313.71
Formula C15H13ClNNaO3
CAS Number 64092-48-4
Purity >98%
Solubility 100 mg/mL in water
Storage at -20°C
References

[1] Iwamura A, et al. Drug Metab Dispos. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Zomepirac sodium salt, McN-2783-21-98 supplier, PGE synthase, inhibitors

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