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Sinapinic acid (Sinapic acid) is derived from Hydnophytum formicarum Jack. The phenolic compounds isolated from the roots were inhibitors of HDAC with an IC50 value of 2.27 mM and also inhibited the activity of AC-I. Sinapinic acid has effective antitumor activity and can induce apoptosis of tumor cells. Sinapinic acid has antioxidant and anti - diabetic effects. Sinapinic acid can reduce total cholesterol, triglyceride and HOMA-IR index in ovariectomized rats, and normalize some serum parameters of antioxidant capacity and oxidative damage.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 224.21 |
| Formula | C11H12O5 |
| CAS Number | 530-59-6 |
| Purity | >99% |
| Solubility | DMSO ≥ 40 mg/mL |
| Storage | RT , protect from light , dry , sealed |
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RTS-V5 is an inhibitor of HDAC/proteasomes, against HDAC1, HDAC2, HDAC3, HDAC6, HDAC8IC50They were 6.9, 18, 15, 0.27, 0.53 μM, respectively. |
| FT895
FT895 is a potent and selective HDAC11 inhibitor,IC50 3 nM. |
| SW-100
SW-100 is a potent inhibitor of histone deacetylase 6 (HDAC6),IC50 The value is 2.3 nM, which is at least 1000 times more selective for HDAC6 than other HDAC enzymes. Sw-100 significantly improves the ability to cross the blood-brain barrier. |
| Tucidinostat (Chidamide) HCl
Tucidinostat (HBI-8000; Chidamide; CS-055) HCl is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10 with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively. |
| ACY-775
ACY-775 is a potent and selective HDAC6 inhbiitor with IC50 of 7.5 nM. |
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