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Sinapinic acid

Cat. No. M11466
Sinapinic acid  Structure
Synonym:

Sinapic acid

Size Price Availability Quantity
100mg USD 62  USD62 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Sinapinic acid (Sinapic acid) is derived from Hydnophytum formicarum Jack. The phenolic compounds isolated from the roots were inhibitors of HDAC with an IC50 value of 2.27 mM and also inhibited the activity of AC-I. Sinapinic acid has effective antitumor activity and can induce apoptosis of tumor cells. Sinapinic acid has antioxidant and anti - diabetic effects. Sinapinic acid can reduce total cholesterol, triglyceride and HOMA-IR index in ovariectomized rats, and normalize some serum parameters of antioxidant capacity and oxidative damage.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 224.21
Formula C11H12O5
CAS Number 530-59-6
Purity >99%
Solubility DMSO ≥ 40 mg/mL
Storage RT , protect from light , dry , sealed
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Keywords: Sinapinic acid , Sinapic acid supplier, HDAC, inhibitors

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