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Sinapinic acid

Cat. No. M11466
Sinapinic acid  Structure
Synonym:

Sinapic acid

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100mg USD 62  USD62 In stock
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Quality Control & Documentation
Biological Activity

Sinapinic acid (Sinapic acid) is derived from Hydnophytum formicarum Jack. The phenolic compounds isolated from the roots were inhibitors of HDAC with an IC50 value of 2.27 mM and also inhibited the activity of AC-I. Sinapinic acid has effective antitumor activity and can induce apoptosis of tumor cells. Sinapinic acid has antioxidant and anti - diabetic effects. Sinapinic acid can reduce total cholesterol, triglyceride and HOMA-IR index in ovariectomized rats, and normalize some serum parameters of antioxidant capacity and oxidative damage.

Chemical Information
Molecular Weight 224.21
Formula C11H12O5
CAS Number 530-59-6
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage RT, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Eun Hye Lee, et al. Cells. Sinapic Acid Controls Inflammation by Suppressing NLRP3 Inflammasome Activation

[2] Anandakumar Pandi, et al. Mol Biol Rep. Pharmacological and therapeutic applications of Sinapic acid-an updated review

[3] Balwinder Singh, et al. Food Res Int. Phenolic composition, antioxidant potential and health benefits of citrus peel

[4] Tzu-Heng Chen, et al. Nanoscale. Sinapinic acid-directed synthesis of gold nanoclusters and their application to quantitative matrix-assisted laser desorption/ionization mass spectrometry

[5] Vasantha Madhuri Kallakunta, et al. Biochim Biophys Acta. Sinapinic acid can replace ascorbate in the biotin switch assay

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Keywords: Sinapinic acid , Sinapic acid supplier, HDAC, inhibitors, activators


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