Sinapinic acid (Sinapic acid) is derived from Hydnophytum formicarum Jack. The phenolic compounds isolated from the roots were inhibitors of HDAC with an IC50 value of 2.27 mM and also inhibited the activity of AC-I. Sinapinic acid has effective antitumor activity and can induce apoptosis of tumor cells. Sinapinic acid has antioxidant and anti - diabetic effects. Sinapinic acid can reduce total cholesterol, triglyceride and HOMA-IR index in ovariectomized rats, and normalize some serum parameters of antioxidant capacity and oxidative damage.
Molecular Weight | 224.21 |
Formula | C11H12O5 |
CAS Number | 530-59-6 |
Solubility (25°C) | DMSO ≥ 40 mg/mL |
Storage | RT, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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