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Siguazodan

Cat. No. M27861

All AbMole products are for research use only, cannot be used for human consumption.

Siguazodan Structure
Synonym:

SKF 94836

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Quality Control & Documentation
Biological Activity

Siguazodan (SKF 94836) is a potent, selective and orally active phosphodiesterase III (PDE-III) inhibitor with an IC50 of 117 nM. Siguazodan increases cAMP accumulation in intact platelets with an EC50 of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC50 value of 4.2 μM.

Chemical Information
Molecular Weight 284.32
Formula C14H16N6O
CAS Number 115344-47-3
Form Solid
Solubility (25°C) DMSO 12.5 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] C K Billington, et al. Am J Physiol. Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition

[2] Y Qian, et al. Br J Pharmacol. Effects of rolipram and siguazodan on the human isolated bronchus and their interaction with isoprenaline and sodium nitroprusside

[3] D C Underwood, et al. J Pharmacol Exp Ther. Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs

[4] N C Turner, et al. Br J Pharmacol. Relaxation of guinea-pig trachea by cyclic AMP phosphodiesterase inhibitors and their enhancement by sodium nitroprusside

[5] K J Murray, et al. Br J Pharmacol. The effects of siguazodan, a selective phosphodiesterase inhibitor, on human platelet function

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Keywords: Siguazodan, SKF 94836 supplier, PDE, inhibitors, activators

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