SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G.
|Solubility (25°C)||DMSO 50 mg/mL
Ethanol 5 mg/mL
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Thea Bismo Strm, et al. Bone morphogenetic protein 1 cleaves the linker region between ligand-binding repeats 4 and 5 of the LDL receptor and makes the LDL receptor non-functional
 Grant R Campbell, et al. Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy
 Parag P Shah, et al. Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L
|Related Cathepsin Products|
LHVS is a potent, non-selective, irreversible, cell-permeable inhibitor of cysteine protease and cathepsin. lHVS reduces actin ring formation. lHVS inhibits T. gondii invasion with an IC50 of 10 μM.
Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase.
LY 3000328 is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively.
|Cysteine Protease inhibitor hydrochloride
Cysteine Protease inhibitor hydrochloride is an inhibitor of cysteine protease. IC50 & Target: Cysteine Protease
|Cysteine Protease inhibitor
Cysteine Protease inhibitor is an inhibitor of cysteine protease. IC50 & Target: Cysteine Protease
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