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Setiptiline

Cat. No. M30309

All AbMole products are for research use only, cannot be used for human consumption.

Setiptiline Structure
Synonym:

Org-8282

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Quality Control & Documentation
Biological Activity

Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.

Chemical Information
Molecular Weight 261.36
Formula C19H19N
CAS Number 57262-94-9
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Michele Protti, et al. Med Res Rev. New-generation, non-SSRI antidepressants: Drug-drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others

[2] A Ishii, et al. Leg Med (Tokyo). Sensitive determination of mianserin and setiptiline in body fluids by gas chromatography with surface ionization detection (GC-SID)

[3] H Kodama. Nihon Shinkei Seishin Yakurigaku Zasshi. [Effect of lithium, carbamazepine, and setiptiline on diacylglycerol in rat brain ex vivo]

[4] M Kuniyoshi, et al. Prog Neuropsychopharmacol Biol Psychiatry. Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia

[5] K Yamada, et al. Nihon Yakurigaku Zasshi. [Behavioral effects of a new antidepressant, setiptiline]

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Keywords: Setiptiline, Org-8282 supplier, 5-HT Receptor, inhibitors, activators

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