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Scopolamine hydrobromide trihydrate

Cat. No. M10294
Scopolamine hydrobromide trihydrate Structure
Synonym:

Scopolamine HBr trihydrate

Size Price Availability Quantity
50mg USD 45  USD50 In stock
100mg USD 63  USD70 In stock
200mg USD 99  USD110 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. Scopolamine HBr trihydrate is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 438.31
Formula C17H28BrNO7
CAS Number 6533-68-2
Purity >99%
Solubility Water 50 mg/mL
Storage 2-8°C, dry, sealed, protect from light
References

NTP Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies)
Natl Toxicol Program Tech Rep Ser. 1997 Mar;445:1-277. PMID: 12594530.

Effect of Dietary Restriction on Toxicology and Carcinogenesis Studies in F344/N Rats and B6C3F1 Mice
Natl Toxicol Program Tech Rep Ser. 1997 Sep;460:1-414. PMID: 12587016.

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