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Scopolamine hydrobromide trihydrate

Cat. No. M10294
Scopolamine hydrobromide trihydrate Structure
Synonym:

Scopolamine HBr trihydrate

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 70  USD70 In stock
200mg USD 110  USD110 In stock
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Quality Control & Documentation
Biological Activity

Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. Scopolamine HBr trihydrate is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics.

Chemical Information
Molecular Weight 438.31
Formula C17H28BrNO7
CAS Number 6533-68-2
Solubility (25°C) Water 50 mg/mL
DMSO 50 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Natl Toxicol Program Tech Rep Ser. NTP Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CAS No. 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies)

[2] Natl Toxicol Program Tech Rep Ser. Effect of Dietary Restriction on Toxicology and Carcinogenesis Studies in F344/N Rats and B6C3F1 Mice

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