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Sanguinarine chloride is a inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Sanguinarine chloride also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Sanguinarine chloride blocks cell cycle in the G1 phase; Sanguinarine chloride inhibits cell growth in human prostate carcinoma cells.
| Molecular Weight | 367.78 |
| Formula | C20H14ClNO4 |
| CAS Number | 5578-73-4 |
| Solubility (25°C) | DMSO 3.8 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
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