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Sanggenone-C

Cat. No. M4504

All AbMole products are for research use only, cannot be used for human consumption.

Sanggenone-C Structure
Size Price Availability Quantity
5mg USD 300  USD300 In stock
10mg USD 490  USD490 In stock
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Quality Control & Documentation
Biological Activity

Sanggenon C is a flavanone diels-Alder adduct compound isolated from the root bark of the genus Morus Cathayana. Sanggenon C plays a protective role in cardiac hypertrophy and fibrosis by inhibiting the calcineurin /NFAT2 pathway. Sanggenon C inhibited the expression of inducible nitric oxide synthase, tumor necrosis factor -α -stimulated cell adhesion and vascular cell adhesion molecule-1 in RAW264.7 cells by inhibiting NF-κB activity. Sanggenon C had antioxidant and anti-inflammatory effects, and also inhibited pancreatic lipase (PL) with IC50 of 3.00 μM.

Chemical Information
Molecular Weight 708.71
Formula C40H36O12
CAS Number 80651-76-9
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Zheng-Hao Yin, et al. Synergistic effects and antityrosinase mechanism of four plant polyphenols from Morus and Hulless Barley

[2] Xu-Dong Hou, et al. Natural constituents from Cortex Mori Radicis as new pancreatic lipase inhibitors

[3] Yang Gu, et al. Sanggenon C protects against cardiomyocyte hypoxia injury by increasing autophagy

[4] Lili Xiao, et al. Sanggenon C protects against pressure overload‑induced cardiac hypertrophy via the calcineurin/NFAT2 pathway

[5] Hongbiao Huang, et al. Sanggenon C decreases tumor cell viability associated with proteasome inhibition

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Keywords: Sanggenone-C supplier, NF-κB, inhibitors, activators

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