Sanggenon C is a flavanone diels-Alder adduct compound isolated from the root bark of the genus Morus Cathayana. Sanggenon C plays a protective role in cardiac hypertrophy and fibrosis by inhibiting the calcineurin /NFAT2 pathway. Sanggenon C inhibited the expression of inducible nitric oxide synthase, tumor necrosis factor -α -stimulated cell adhesion and vascular cell adhesion molecule-1 in RAW264.7 cells by inhibiting NF-κB activity. Sanggenon C had antioxidant and anti-inflammatory effects, and also inhibited pancreatic lipase (PL) with IC50 of 3.00 μM.
| Molecular Weight | 708.71 |
| Formula | C40H36O12 |
| CAS Number | 80651-76-9 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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