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Salvianolic-acid-A

Cat. No. M4139
Salvianolic-acid-A Structure
Size Price Availability Quantity
20mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Salvianolic-acid-A

Chemical Information
Molecular Weight 494.44
Formula C26H22O10
CAS Number 96574-01-5
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wi-Jin Jeon, et al. Salvianolic Acid A Suppresses DNCB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice

[2] Cai Zhang, et al. Salvianolic acid A increases the accumulation of doxorubicin in brain tumors through Caveolae endocytosis

[3] Tian Qin, et al. Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways

[4] Rong Wang, et al. Salvianolic acid A attenuates CCl 4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways

[5] Hong-Feng Zhang, et al. Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3 β/Nrf2 Signaling Pathway and Inhibiting the NF- κ B Signaling Pathway in 5/6 Nephrectomized Rats

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