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S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies.
| Molecular Weight | 502.49 |
| Formula | C27H21F3N6O |
| CAS Number | 1257628-57-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 32 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, sealed |
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