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RU 24969

Cat. No. M13875

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RU 24969 Structure
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Biological Activity

RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion.

Chemical Information
Molecular Weight 228.29
CAS Number 66611-26-5
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Sanders A McDougall, et al. Reciprocal cross-sensitization between cocaine and RU 24969 in male and female preweanling rats

[2] Sanders A McDougall, et al. Importance of dopaminergic neurotransmission for the RU 24969-induced locomotor activity of male and female rats during the preweanling period

[3] Sanders A McDougall, et al. Effects of repeated RU 24969 treatment on the locomotor activity, motoric capacity, and axillary temperatures of male and female preweanling rats

[4] Dane Aronsen, et al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms

[5] P J Fletcher, et al. RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors

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Keywords: RU 24969 supplier, 5-HT Receptor, inhibitors, activators

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