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(RS)-MCPG

Cat. No. M14015

All AbMole products are for research use only, cannot be used for human consumption.

(RS)-MCPG Structure
Synonym:

alpha-MCPG

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Quality Control & Documentation
Biological Activity

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.

Chemical Information
Molecular Weight 209.2
CAS Number 146669-29-6
Solubility (25°C) 1M NaOH 90 mg/mL (ultrasonic and adjust pH to 10 with NaOH)
DMSO 6 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] J H Kim, et al. The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats

[2] S J Martin, et al. (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo

[3] R E Brown, et al. (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) does not block theta burst-induced long-term potentiation in area CA1 of rat hippocampal slices

[4] O J Manzoni, et al. MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus

[5] N B Keele, et al. Agonist action of (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) in the amygdala

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Keywords: (RS)-MCPG, alpha-MCPG supplier, GluR, inhibitors, activators

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