Rotundine

Cat. No. M19276

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

(-)-Tetrahydropalmatine; L-Tetrahydropalmatine

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Quality Control & Documentation

Purity: >99.0%
COA
MSDS

Product Information

Biological Activity

Rotundine is an antagonist of 5-HT1A with an IC50 of 370 nM. Rotundine is also an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively.

Chemical Information

Molecular Weight	355.43
Formula	C21H25NO4
CAS Number	483-14-7
Form	Solid
Solubility (25°C)	DMSO ≥ 80 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Weijian Li, et al. J Org Chem. Total Synthesis of (-)-Canadine, (-)-Rotundine, (-)-Sinactine, and (-)-Xylopinine Using a Last-Step Enantioselective Ir-Catalyzed Hydrogenation

[2] Kwangho Song, et al. Molecules. Molecular Network-Guided Alkaloid Profiling of Aerial Parts of Papaver nudicaule L. Using LC-HRMS

[3] Jun-Ping Li, et al. Guang Pu Xue Yu Guang Pu Fen Xi. [IR and Raman spectra studies of Rotundine based on DFT]

[4] Chun-zheng Li, et al. Yao Xue Xue Bao. [In vitro O-demethylation of rotundine by recombinant human CYP isoenzymes]

[5] L Li, et al. J Pharm Sci. Influence of light and heat on the stability of rotundine sulfate injection

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Rotundine

(-)-Tetrahydropalmatine; L-Tetrahydropalmatine

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