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RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity.
| Molecular Weight | 373.21 |
| Formula | C14H5F6N5O |
| CAS Number | 691868-88-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | -20°C, sealed |
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