Certificate of Analysis
| Product Name: | RO8191 |
| Catalog Number: | M30500 |
| CAS Number: | 691868-88-9 |
Physical and Chemical Properties
| Formula: | C14H5F6N5O |
| Molecular Weight: | 373.21 |
| Form: | Solid |
| Solubility: | DMSO 5 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage: | -20°C, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥98.5% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |