RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2).
| Molecular Weight | 389.24 |
| Formula | C17H14Cl2N6O |
| CAS Number | 1258296-60-4 |
| Solubility (25°C) | DMSO 78 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related JAK Products |
|---|
| Londamocitinib
Londamocitinib is a potent and selective JAK1 inhibitor with anti-inflammatory activity. |
| SJ1008030 TFA
SJ1008030 TFA is a JAK2 PROTAC which selectively degrades JAK2. |
| DPP
DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand. |
| STAT3-IN-18
STAT3-IN-18 is a platinum (IV) complex with an axial ligand derived from sandalwood. |
| JAK-IN-28
JAK-IN-28 is a JAK inhibitor. |
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