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RO495

Cat. No. M20744
RO495 Structure
Synonym:

CS-2667

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 389.24
Formula C17H14Cl2N6O
CAS Number 1258296-60-4
Purity >99%
Solubility DMSO 78 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog




Keywords: RO495, CS-2667 supplier, JAK, inhibitors

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