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RIG012 is a potent RIG-I antagonist that blocks RIG-I-initiated signaling, inhibits transcriptional induction of CXCL10, IFN-β 1, and IRF9, and reduces IL6 mRNA levels. The IC50 was 0.71 μM when assayed with NADH-coupled ATPase.
| Molecular Weight | 359.42 |
| Formula | C23H21NO3 |
| CAS Number | 2642218-43-5 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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