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Rhamnocitrin

Cat. No. M19074
Rhamnocitrin Structure
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5mg USD 225  USD225 In stock
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Biological Activity

Rhamnocitrin

Chemical Information
CAS Number 569-92-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dinesh Kumar Patel. Drug Metab Bioanal Lett. Biological importance and therapeutic benefit of rhamnocitrin: A review of pharmacology and analytical aspects

[2] Yanyuan Zhou, et al. Oxid Med Cell Longev. Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome

[3] Tong Lin, et al. Phytomedicine. Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3

[4] Seung Cheol Baek, et al. Bioorg Chem. Rhamnocitrin isolated from Prunus padus var. seoulensis: A potent and selective reversible inhibitor of human monoamine oxidase A

[5] Yi-Chen Tu, et al. J Agric Food Chem. Antiatherogenic effects of kaempferol and rhamnocitrin

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