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RGX-104

Cat. No. M10589

All AbMole products are for research use only, cannot be used for human consumption.

RGX-104 Structure
Synonym:

SB 742881; RGX-104 free form

Size Price Availability Quantity
5mg USD 115  USD115 In stock
10mg USD 180  USD180 In stock
25mg USD 350  USD350 In stock
50mg USD 540  USD540 In stock
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Quality Control & Documentation
Biological Activity

RGX-104, also known as SB 742881, is a liver X receptor beta (LXR) agonist with potential immunomodulating and antineoplastic activities. RGX-104 modulates innate immunity via transcriptional activation of the ApoE gene.

Oral administration of RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.

Chemical Information
Molecular Weight 596.08
Formula C34H33ClF3NO3
CAS Number 610318-54-2
Solubility (25°C) DMSO 90 mg/mL
Storage 2-8°C, protect from light, sealed
References

[1] Masoud F Tavazoie, et al. Cell. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

[2] Karpagam Aravindhan, et al. J Lipid Res. Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study

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Keywords: RGX-104, SB 742881; RGX-104 free form supplier, Liver X Receptor, inhibitors, activators

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