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RGX-104 hydrochloride

Cat. No. M10627
RGX-104 hydrochloride Structure
Synonym:

RGX104 HCl

Size Price Availability
2mg USD 122  USD122 4-7 Days
5mg USD 207  USD207 4-7 Days
25mg USD 596  USD596 4-7 Days
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Quality Control & Documentation
Biological Activity

RGX-104 hydrochloride is a small-molecule LXR (liver X receptor) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. Oral administration of RGX-104 hydrochloride to animals bearing palpable tumors significantly suppresses the growth of multiple cancer types. Responses are seen across a wide spectrum of malignancies, including lung cancer, melanoma, glioblastoma, and ovarian, renal cell, triple-negative breast, and colon cancer.

Chemical Information
Molecular Weight 632.54
Formula C34H34Cl2F3NO3
CAS Number 610318-03-1
Solubility (25°C) DMSO ≥ 70 mg/mL (May need warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Masoud F Tavazoie, et al. Cell . LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

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Keywords: RGX-104 hydrochloride, RGX104 HCl supplier, Liver X Receptor, inhibitors, activators


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