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Renzapride

Cat. No. M27821

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Renzapride Structure
Synonym:

BRL 24924

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Quality Control & Documentation
Biological Activity

Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study.

Chemical Information
Molecular Weight 323.82
Formula C16H22ClN3O2
CAS Number 112727-80-7
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shilan Mozaffari, et al. Arch Med Sci. Efficacy and tolerability of renzapride in irritable bowel syndrome: a meta-analysis of randomized, controlled clinical trials including 2528 patients

[2] A C Ford. Aliment Pharmacol Ther. Renzapride in IBS: is efficacy in the eye of the beholder?

[3] Emidio Scarpellini, et al. Expert Opin Investig Drugs. Renzapride: a new drυg for the treatment of constipation in the irritable bowel syndrome

[4] Nicholas L Meyers, et al. Drugs R D. Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome

[5] Michael Camilleri, et al. Clin Gastroenterol Hepatol. Effect of renzapride on transit in constipation-predominant irritable bowel syndrome

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Keywords: Renzapride, BRL 24924 supplier, 5-HT Receptor, inhibitors, activators

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