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Recombinant Mouse IL-11 (HEK 293)

Cat. No. M45205

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse IL-11 (HEK 293) Structure
Synonym:

Interleukin-11

Size Price Availability Quantity
10ug USD 220  USD220 In stock
50ug USD 700  USD700 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Interleukin-11 (IL-11) is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 can stimulate the T cell dependent development of specific immunoglobulin-secreting B cell.

Measured in a cell proliferation assay using TF-1 cells, the ED50 is < 3.0 ng/ml.

Recombinant Mouse IL-11 expressed the target gene encoding Gly23-Leu199.


Accession: P47873

Endotoxin < 0.2 EU/μg

Apparent Molecular Weight: ~21 kDa, reducing conditions

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for up to 6 months after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added.
References

[1] Ding Zuo, et al. J Stroke Cerebrovasc Dis. Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Rα/STAT3 signaling pathway

[2] Javier Milara, et al. Respir Res. IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis

[3] Na Peng, et al. Anticancer Agents Med Chem. Recombinant Human IL-11 Promotes Lung Adenocarcinoma A549 Cell Growth and EMT through Activating STAT3/HIF-1α/EMT Signaling Pathway

[4] Galina Shepelkova, et al. J Infect Dis. Therapeutic Effect of Recombinant Mutated Interleukin 11 in the Mouse Model of Tuberculosis

[5] A J Dorner, et al. BioDrugs. Interleukin-11

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Keywords: Recombinant Mouse IL-11 (HEK 293), Interleukin-11 supplier, Cytokines and Growth Factors, inhibitors, activators

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