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Recombinant Human IL-29/IFN-λ1 (Mammalian, C-10His)

Cat. No. M55325
Recombinant Human IL-29/IFN-λ1 (Mammalian, C-10His) Structure
Synonym:

Interleukin-29; Interferon lambda-1; IFN-lambda-1

Size Price Availability Quantity
10ug USD 160  USD160 In stock
50ug USD 390  USD390 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Interleukin-29 (IL-29; IFN-λ1) is a cytokine with immunomodulatory activity. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Recombinant Human IL-29/IFN-λ1 expressed the target gene encoding Gly20-Thr200 with a 10His tag at the C-terminus.


Accession: Q8IU54

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 25-36 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human IL-29/IFN-λ1 (Mammalian, C-10His), Interleukin-29; Interferon lambda-1; IFN-lambda-1 supplier, Recombinant Proteins, inhibitors, activators


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