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Recombinant Human IGF-1 LR3 Protein is a mitogenic polypeptide growth factor that can stimulate the proliferation and survival of various cells, including muscle, bone and cartilage tissue. Recombinant Human IGF-1 LR3 is a recombinant analog of human IGF-I and consists of the complete IGF-I sequence , The third glutamic acid is replaced by arginine, and the N-terminal peptide extends 13 amino acids. The isolated IGF-ILR 3 designed for higher biological efficacy has an increased half-life and an aversion to the binding of natural proteins in the body, making it an ideal choice for research and large-scale cultivation.
The recombinant human IGF1 consists of 83 amino acids and predicts a molecular mass of 9.1 kDa. A DNA sequence encoding the human IGF1 (P05019-1) (Gly49-Ala118, with mutation Glu 51 Arg) was expressed with a 13 amino acids (MFPAMPLSSLFVN) at its N-terminus.
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells, the ED50 for this effect is typically 1.5-6 ng/mL.
Accession: P05019-1
Endotoxin < 0.1 EU/µg
Lyophilized from sterile PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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