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GDNF is an important member of the GDNF family of ligands. GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption.
The recombinant rat GDNF consists of 150 amino acids and predicts a molecular mass of 17.1 KDa. A DNA sequence encoding the mature form of rat GDNF (Ser78-Ile211) was expressed, with a polyhistide tag at the N-terminus.
Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells, the ED50 for this effect is typically 10-50 ng/mL in the presence of Recombinant Rat GFR alpha‑1/GDNF R alpha‑1 His Chimera.
Accession: Q07731-1
Apparent Molecular Weight: 20 KDa, under reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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