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Recombinant Human IFN-λ1 Protein

Cat. No. M9997
Recombinant Human IFN-λ1 Protein Structure
Synonym:

rhIL-29

Size Price Availability Quantity
50ug USD 432  USD480 In stock
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Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin ≤0.01EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human IFN-λ1 Protein uses an independent receptor system consisting of IFN-λR1 subunit (also called CRF 2-12) and IL-10R2 subunit (also called CRF 2-14) to induce an antiviral defense similar to type I interferon, but different from type I interferon. 

Recombinant human IFN-λ1 protein contains 184 amino acids and has a predicted molecular weight of 20.6kd. 

Depends on its ability to activate STAT phosphorylation, which was analyzed in the ISRE luciferase report using human colon cancer COLO205 cells, expected ED50 is 0.2-0.5 ng/ml. 

Expression host is Human HEK293 cells

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity ≥95%, Endotoxin ≤0.01EU/ug
Solubility Water
Saline
PBS
Storage 2-8°C, dry, sealed
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  Catalog
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