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r8 Bid BH3

Cat. No. M41323
r8 Bid BH3 Structure
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Biological Activity

r8 Bid BH3 is a biological active peptide.

Chemical Information
Molecular Weight 3616.1
Formula C145H260N66O41S
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alex D Chacko et al. Apoptosis. Machine vision based stochastic analysis of cancer cell mitochondrial dysfunction induced by a BH3 domain

[2] Rongxiu Li et al. Neoplasia. Targeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head and neck squamous cell carcinoma cells

[3] K C Goldsmith et al. Oncogene. BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma

[4] Linda Strandberg Ihrlund et al. Exp Cell Res. Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1

[5] Theocharis Panaretakis et al. Oncogene. Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax

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Keywords: r8 Bid BH3 supplier, Bcl-2, inhibitors, activators

 
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