Free shipping on all orders over $ 500

(R)-Lisofylline

Cat. No. M27603

All AbMole products are for research use only, cannot be used for human consumption.

(R)-Lisofylline Structure
Synonym:

(R)-Lisophylline

Size Price Availability Quantity
1mg USD 150  USD150 In stock
5mg USD 300  USD300 In stock
10mg USD 480  USD480 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research.

Chemical Information
Molecular Weight 280.32
Formula C13H20N4O3
CAS Number 100324-81-0
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage -20°C, sealed
References

[1] Paolo Schiavini, et al. Chembiochem. Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity

[2] Nikolaos Drosos, et al. Angew Chem Int Ed Engl. Boron-Catalyzed Regioselective Deoxygenation of Terminal 1,2-Diols to 2-Alkanols Enabled by the Strategic Formation of a Cyclic Siloxane Intermediate

Related STAT Products
HP590 

HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM).

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 

STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3.

HJC0123

HJC0123 is a novel STAT3 inhibitor that suppresses the fibrogenic properties of HSCs. HJC0123 reduced the phosphorylation, nuclear translocation, and transcriptional activity of STAT3. HJC0123 treatment resulted in the inhibition of HSCs proliferation at submicromolar concentrations. It decreased the expression of STAT3-regulated proteins, induced cell cycle arrest, promoted apoptosis and downregulated SOCS3.

ODZ10117

ODZ10117 is a small molecule inhibitor of STAT3. ODZ10117 inhibited migration and invasion and induced apoptotic cell death by targeting STAT3 in glioblastoma cells.

OPB-111077

OPB-111077 is a first-in-class, novel, oral inhibitor of STAT3 and mitochondrial oxidative phosphorylation (OXPHOS) with anticancer activity. OPB-111077 inhibits mitochondrial respiratory chain complex I, which leads to inhibition of energy production and activation of the AMPK-mTOR energy stress sensor pathway.

  Catalog
Abmole Inhibitor Catalog




Keywords: (R)-Lisofylline, (R)-Lisophylline supplier, STAT, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.