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Quercetin dimer

Cat. No. M16710
Quercetin dimer Structure
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Biological Activity

Quercetin dimer

Chemical Information
CAS Number 167276-19-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Francesco Di Pierro, et al. Int J Gen Med. Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial

[2] Xican Li, et al. Antioxidants (Basel). Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-Alder anti-Dimer on Erastin-Induced Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells

[3] Mario C Foti, et al. Biophys Chem. Singlet oxygen quenching- and chain-breaking antioxidant-properties of a quercetin dimer able to prevent age-related macular degeneration

[4] Limei Wang, et al. Biochem Pharmacol. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

[5] Hyeon-Joong Kim, et al. Arch Pharm Res. Differential effects of quercetin glycosides on GABAC receptor channel activity

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