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Ayanin

Cat. No. M16832
Ayanin Structure
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Biological Activity

Ayanin

Chemical Information
CAS Number 572-32-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ninh The Son. Evid Based Complement Alternat Med. Genus Miliusa: A Review of Phytochemistry and Pharmacology

[2] Bei-Dou Zhou, et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents from stems and leaves of Psychotria serpens]

[3] Amira Arciniegas, et al. Chem Biodivers. Chemical Composition and Antimicrobial Activity of Ageratina deltoidea

[4] Mara Teresa Marrero, et al. Biochem Biophys Res Commun. Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells

[5] Fei-Peng Lee, et al. Eur J Pharmacol. Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia

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