Psammaplin A is a Marine metabolite that acts as a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A is a highly selective HDAC1 inhibitor with an IC50 of 0.9 nM, which is 360 times more selective to HDAC1 than DAC6 and more than 1000 times less potent to HDAC7 and HDAC8.
Molecular Weight | 664.39 |
Formula | C22H24Br2N4O6S2 |
CAS Number | 110659-91-1 |
Solubility (25°C) | N/A |
Storage | 2-8℃, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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