Free shipping on all orders over $ 500

Psammaplin A

Cat. No. M21595
Psammaplin A  Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Psammaplin A is a Marine metabolite that acts as a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A is a highly selective HDAC1 inhibitor with an IC50 of 0.9 nM, which is 360 times more selective to HDAC1 than DAC6 and more than 1000 times less potent to HDAC7 and HDAC8.

Chemical Information
Molecular Weight 664.39
Formula C22H24Br2N4O6S2
CAS Number 110659-91-1
Solubility (25°C) N/A
Storage 2-8℃, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qinxue Jing, et al. Mar Drugs. Marine-Derived Natural Lead Compound Disulfide-Linked Dimer Psammaplin A: Biological Activity and Structural Modification

[2] Raffaella Cincinelli, et al. Eur J Med Chem. Camptothecin-psammaplin A hybrids as topoisomerase I and HDAC dual-action inhibitors

[3] Malcolm W B McCulloch, et al. Bioorg Med Chem. Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives

[4] Yahong Jiang, et al. BMC Cancer. Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication

[5] J N Tabudravu, et al. Bioorg Med Chem. Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax

Related HDAC Products
Ac-Arg-Gly-Lys(Ac)-AMC

Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC.

Chlamydocin

Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM.

HDAC-IN-30

HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC50=13.4 nM),HDAC2 (IC50=28.0 nM), HDAC3 (IC50=9.18 nM), HDAC6 (IC50=42.7 nM), HDAC8 (IC50=131 nM).

Ac-Arg-Gly-Lys(Ac)-AMC acetate

Ac-Arg-Gly-Lys(Ac)-AMC acetate is a substrate for histone deacetylase (HDAC) and can be used in a novel fluorescent assay for HDAC activity.

JPS014 TFA

JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC).

  Catalog
Abmole Inhibitor Catalog




Keywords: Psammaplin A supplier, HDAC, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.