All AbMole products are for research use only, cannot be used for human consumption.
Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent agonist of PAR2 with IC50 of 10.4 uM. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation factors VIIa and Xa, cleave a specific extracellular amino-terminal domain of the receptor to reveal a "tethered ligand", SLIGKV- and SLIGRL- for human and mouse/rat PAR2, respectively, which subsequently interacts with the activation domain of the receptor, initiating intracellular signaling pathways.
| Molecular Weight | 614.78 |
| Formula | C28H54N8O7 |
| CAS Number | 190383-13-2 |
| Solubility (25°C) | Water 30 mg/mL |
| Storage | -20°C, sealed |
| Related PAR Products |
|---|
| SCH79797 dihydrochloride
SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. |
| TRAP-6 amide
TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide. |
| Protease-Activated Receptor-1, PAR-1 Agonist
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. |
| FSLLRY-NH2
FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor. |
| iso-TRAP-6
iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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