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Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs. BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment.
Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Molecular Weight | 128.13 |
| Formula | C6H8O3 |
| CAS Number | 55683-37-9 |
| Form | Liquid (density 1.140 g/mL) |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage | Pure form -20°C |
| Related PROTAC Linker Products |
|---|
| m-PEG2-acid
m-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
| HO-PEG14-OH
HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| NH2-PEG3-C2-Boc
NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| NH2-PEG3-C1-Boc
NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
| Amino-PEG9-amine
Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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