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Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent, it is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).
| Molecular Weight | 456.36 |
| Formula | C18H20N2O12 |
| CAS Number | 70539-42-3 |
| Solubility (25°C) | DMSO 90 mg/mL acetic acid: water (1:1): ≤50 mg/mL DMF: soluble |
| Storage | 2-8°C, dry, sealed |
| Related PROTAC Linker Products |
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| Azido-PEG2-CH2COOH
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. |
| Propargyl-PEG1-acid
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs. BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
| m-PEG2-acid
m-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
| HO-PEG14-OH
HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| NH2-PEG3-C2-Boc
NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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