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EGNHS

Cat. No. M10135
EGNHS Structure
Synonym:

Ethlene Glycol Bis(Succinimidyl Succinate)

Size Price Availability Quantity
100mg USD 100  USD100 In stock
250mg USD 200  USD200 In stock
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Quality Control
  • Current batch:
  • Purity BR
  • COA
  • MSDS
Biological Activity

Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent, it is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 456.36
Formula C18H20N2O12
CAS Number 70539-42-3
Purity BR
Solubility acetic acid: water (1:1): ≤50 mg/mL
DMF: soluble
Storage 2-8°C, dry, sealed
References

[1] Yonghan He, et al. J Hematol Oncol. Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

[2] Sainan An, et al. EBioMedicine. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

[3] Evgeniy V Petrotchenko, et al. Mol Cell Proteomics. Isotopically coded cleavable cross-linker for studying protein-protein interaction and protein complexes

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Keywords: EGNHS, Ethlene Glycol Bis(Succinimidyl Succinate) supplier, PROTAC Linker, inhibitors

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