Certificate of Analysis
| Product Name: | Propargyl-PEG1-acid |
| Catalog Number: | M58639 |
| CAS Number: | 55683-37-9 |
Physical and Chemical Properties
| Formula: | C6H8O3 |
| Molecular Weight: | 128.13 |
| Form: | Liquid (density 1.140 g/mL) |
| Solubility: | DMSO 45 mg/mL |
| Storage: | Pure form -20°C |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥97.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs. BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |