Free shipping on all orders over $ 500

Progabide

Cat. No. M31352
Progabide Structure
Synonym:

SL 76002

Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Progabide is a gamma-aminobutyric acid (GABA) receptor agonist that may be used in studies related to epilepsy.

Chemical Information
Molecular Weight 334.77
Formula C17H16ClFN2O2
CAS Number 62666-20-0
Form Solid
Solubility (25°C) DMSO >100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] C Cepeda, et al. Epilepsia. Action of progabide in the photosensitive baboon, Papio papio

[2] J M Martínez-Lage, et al. Epilepsia. Progabide treatment in severe epilepsy: a double-blind cross-over trial versus placebo

[3] H Manev, et al. Pharmacol Biochem Behav. Progabide, a GABA mimetic drug, stimulates the secretion of plasma corticosterone in rats

[4] G H Fromm, et al. Epilepsia. Comparison of progabide with other antiepileptic and GABAergic drugs

[5] K J Bergmann. Clin Neuropharmacol. Progabide: a new GABA-mimetic agent in clinical use

Related GABA Receptor Products
Alogabat

Alogabat (RG-7816) is a GABAA α5 receptor positive allosteric modulators (PAMs).

CGP7930

CGP7930 (3-(3’,5’-Di-tert-butyl-4’-hydroxy) phenyl-2, 2-dimethylpropanol) is a positive metabotropic GABAB receptor allosteric modulator.

5-Aminovaleric acid

5-Aminovaleric acid is a GABA receptor antagonist.

L-2,4-Diaminobutyric acid dihydrochloride

L-2,4-Diaminobutyric acid dihydrochloride inhibits GABA transaminase activity, resulting in elevated GABA levels, and exhibits ex vivo antitumor activity against mouse fibrosarcoma cells. In addition, L-2,4-Diaminobutyric acid dihydrochloride can be used as an internal standard for amino acid analysis.

3,4,5-Trimethoxy-trans-cinnamic acid

(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups.

  Catalog
Abmole Inhibitor Catalog




Keywords: Progabide, SL 76002 supplier, GABA Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.