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Pralidoxime Iodide

Cat. No. M20457
Pralidoxime Iodide Structure
Synonym:

2-PAM

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Biological Activity

Pralidoxime Iodide (2-PAM) is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.

Chemical Information
Molecular Weight 264.06
Formula C7H9IN2O
CAS Number 94-63-3
Solubility (25°C) DMSO 52 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Najmiddin Mamadjonov, et al. PLoS One. Pralidoxime improves the hemodynamics and survival of rats with peritonitis-induced sepsis

[2] Akiko Ozawa. Chudoku Kenkyu. Pralidoxime

[3] Emma Louise Walton. Biomed J. Pralidoxime and pesticide poisoning: A question of severity?

[4] Myles Thomas Quail, et al. Prehosp Emerg Care. Pralidoxime safety and toxicity in children

[5] Koichi Sakurada, et al. Neurochem Res. Pralidoxime iodide (2-pAM) penetrates across the blood-brain barrier

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Keywords: Pralidoxime Iodide, 2-PAM supplier, AChR/AChE, inhibitors, activators


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