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PPNDS tetrasodium 

Cat. No. M27652

All AbMole products are for research use only, cannot be used for human consumption.

PPNDS tetrasodium  Structure

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Quality Control & Documentation
Biological Activity

PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers.

Chemical Information
Molecular Weight 694.36
Formula C18H11N4Na4O14PS2
CAS Number 1021868-77-8
Form Solid
Solubility (25°C) Water 37.5 mg/mL (ultrasonic and warming and heat to 60°C)
Storage -20°C, dry, sealed
References

[1] H C Ferreira-Neto, et al. J Physiol. Purinergic P2 and glutamate NMDA receptor coupling contributes to osmotically driven excitability in hypothalamic magnocellular neurosecretory neurons

[2] Hildebrando Candido Ferreira-Neto, et al. J Neurophysiol. ATP stimulates rat hypothalamic sympathetic neurons by enhancing AMPA receptor-mediated currents

[3] Hua Ren, et al. Infect Immun. Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release

[4] Brian D Gulbransen, et al. Gastroenterology. Purinergic neuron-to-glia signaling in the enteric nervous system

[5] Yanpeng Lin, et al. Neurosci Lett. P2 receptor antagonist PPADS confers neuroprotection against glutamate/NMDA toxicity

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  Catalog
Abmole Inhibitor Catalog




Keywords: PPNDS tetrasodium  supplier, MMP, inhibitors, activators

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