All AbMole products are for research use only, cannot be used for human consumption.
PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. The well performing PKM2-IN-1 (compound 3k) shows nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18-1.56 μM.
Moreover, PKM2-IN-1 (compound 3k) exhibits more cytotoxicity on cancer cells than normal cells.
| Cell Experiment | |
|---|---|
| Cell lines | HCT116, Hela, H1299, BEAS-2B |
| Preparation method | Cell viability is detected with the MTS assay. Briefly, 5000 cells in per well are plated in 96-well plates. After incubated for 12 h, the cells are treated with different concentration of tested compound or DMSO (as negative control) for 48 h. Then 20 μL MTS is added in per well and incubated at 37°C for 3h. Absorbance of each well is determined by a microplate reader at a 490 nm wavelength. The IC50 values are calculated using Prism Graphpad software of the triplicate experiment. |
| Concentrations | 0.078, 0.156, 0.313, 0.625 μM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 345.48 |
| Formula | C18H19NO2S2 |
| CAS Number | 94164-88-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 7 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Pyruvate Kinase Products |
|---|
| Vitamin K5
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. |
| (Rac)-Etavopivat
(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat. |
| ZY-1
ZY-1 is a control molecule of ZY-2. |
| PKR activator 4
PKR activator 4 is a potent pyruvate kinase R (PKR) activator. |
| CIAC001
CIAC001 is a Pyruvate Kinase PKM2 inhibitor with anti-neuroinflammatory activity. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
