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Mitapivat (AG-348) is the first-in-class, oral effective pyruvate kinase small molecule allosteric activator. Mitapivat (AG-348) is active against wild-type and various mutated PKR enzymes, and promotes healthy red blood cell generation by activating mutated PKR to increase ATP levels.
| Molecular Weight | 450.55 |
| Formula | C24H26N4O3S |
| CAS Number | 1260075-17-9 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Rachael F Grace, et al. Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency
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