Physostigmine Salicylate

Cat. No. M2939

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

Eserine Salicylate

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Physostigmine is a parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor.

	Source	Behav Brain Res (2015). Figure 2. Physostigmine Salicylate
	Method	i.p.
	Cell Lines	Sprague-Dawley rats
	Concentrations	0.06 or 0.125 mg/kg
	Incubation Time	24 h
	Results	Post-hoc analysis showed that 2 μg/side dose of physostigmine produced a significant increase in time spent immobile compared to saline

	Source	Behav Brain Res (2015). Figure 1. Physostigmine Salicylate
	Method	i.p.
	Cell Lines	Sprague-Dawley rats
	Concentrations	0.06 or 0.125 mg/kg
	Incubation Time	24 h
	Results	Subsequent examination and analysis of locomotor behavior showed that systemic administration of physostigmine did not alter locomotor activity compared to saline controls

Cell Experiment
Cell lines	Human erythrocyte
Preparation method	Starting at maximum enzyme activity (t=30), erythrocyte AChE was inhibited with a short pulse (4 min) of physostigmine (250 nM) followed by a continuous perfusion of physostigmine (50 nM) for 30 min.
Concentrations	50 nM
Incubation time	30 min

Molecular Weight	413.47
Formula	C15H21N3O2.C7H6O3
CAS Number	57-64-7
Form	Solid
Solubility (25°C)	DMSO 10 mM
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

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